A General Model of Codon Bias Due to GC Mutational Bias
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چکیده
منابع مشابه
A General Model of Codon Bias Due to GC Mutational Bias
BACKGROUND In spite of extensive research on the effect of mutation and selection on codon usage, a general model of codon usage bias due to mutational bias has been lacking. Because most amino acids allow synonymous GC content changing substitutions in the third codon position, the overall GC bias of a genome or genomic region is highly correlated with GC3, a measure of third position GC conte...
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7. Karimpour, I., Cutler, M., Shih, D., Smith, J. and Kleene, K. (1992) DNA Cell Hiol. 11,693-699 8. Hill, K. E., Lloyd, R. S., Yang, J. G., Read, R. and Hurk, R. F. (1991) J. Biol. Chem. 266,10050-10053 9. Burk, R. F., Lawrence, R. A. and Lane, J. M. (1980) J. Clin. Invest. 65, 1024-1031 10. Rurk, R. F., Hill, K. E., Read, R. and Rellew, T. (1991) Am. J. Physiol. 261, E26-E30 11. Yang, J. G., ...
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χ measure. In statistics, the χ statstic computes how different the distribution of values is from a uniform distribution. Let d = c1 . . . cN be a DNA string in nucleotide alphabet, and let L be the total number of codons in d that are not Methinine or Tryptophan (the number does include the stop codons though). Let a be a k-degenerate amino acid, and let La be the total number of codons codin...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0013431